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KMID : 1812720210030030172
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International Journal of Heart Failure
2021 Volume.3 No. 3 p.172 ~ p.178
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Incidence, Cause of Death, and Survival of Amyloidosis in Korea: A Retrospective Population-Based Study
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Jang Shin-Yi
Kim Da-Rae
Choi Jin-Oh
Jeon Eun-Seok
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Abstract
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Background and Objectives: We sought to assess incidence, cause of death, and survival for amyloidosis. We acquired amyloidosis data from the National Health Insurance Service in Korea from 2006 through 2017 (n=2,233; male 53.5%).
Methods: We calculated the age-standardized incidence rate, analyzed the survival rate (SR) using the Kaplan-Meier method, and analyzed the death risk using Cox proportional hazards methods.
Results: The mean age was 57.0±16.7 years in males and 56.8±15.6 years in females (p=0.795). The proportion of death was 34.7%. The causes of death were endocrine, nutritional, and metabolic diseases (33.9%), malignant neoplasm (20.8%), and diseases of the circulatory system (9.68%). The overall age-standardized incidence rate was 0.47 persons per 100,000 persons in 2017. Overall, the 10-year SR for amyloidosis was 57.7%. Adjusted hazard ratios were 9.16 among 40s′, 16.1 among 50s′, 30.3 among 60s′, 48.7 among 70s′, 80.1 among people 80 years or older, and 1.21 in the medium-level socioeconomic position group.
Conclusions: The age-standardized incidence rate of amyloidosis was about 0.5 persons per 100,000 persons in 2017. The 10-year SR of amyloidosis was about 58%. The most common cause of death was endocrine, nutritional, and metabolic diseases. The risk of death from amyloidosis increased with age and medium socioeconomic position.
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KEYWORD
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Incidence, Survival rates, Cause of death, Proportional hazards models, Amyloidosis
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